一、基本信息

冯若飞，在中国农业科学院研究生院获得博士学位，教授，博士研究生导师，兼任甘肃省免疫学会常务理事、甘肃省生物工程学会副理事长。2018年入选国家民委中青年英才计划，主持国家自然科学基金项目等国家级科研项目2项、省部级项目3项，其他科研项目20余项。先后发表学术论文90余篇，出版主编教材1部。主要从事生物工程学科教学科研工作，研究领域为生物医药工程。

联系方式：0931-4515880  fengruofei@xbmu.edu.cn

二、学习经历

1998年9月—2002年7月：西北民族大学，动物科学专业，获农学学士学位

2004年9月—2007年6月：西北民族大学，临床兽医专业，获农学硕士学位

2011年9月—2014年6月：中国农业科学院研究生院，预防兽医专业，获农学博士学位

三、工作经历

2002年7月—2007年12月  西北民族大学生命科学与工程学院  助理实验师

2007年12月—2012年12月 西北民族大学生命科学与工程学院  实验师

22012年12月—2018年6月 西北民族大学生命科学与工程学院  高级实验师

2018年6月—2021年12月  西北民族大学生物医学研究中心副主任、高级实验师、硕士生导师

2021年12月-2022年12月 西北民族大学生物医学研究中心副主任、副教授、博士生导师

2022年12月-2026年1月 西北民族大学生物医学研究中心副主任、教授、博士生导师

2026年1月-至今       西北民族大学生物工程学院副院长（主持工作）、教授、博士生导师

（兼任：2024年7月—至今：甘肃农业大学动物医学院，博士研究生导师）

四、主要获奖、荣誉

1.冯若飞（1/5），科研成果，甘肃省人民政府，甘肃省科技进步奖，三等奖，2026年

2.冯若飞（1/1），甘肃省教育厅，甘肃省优秀硕士学位论文指导教师，2021年

3.冯若飞（1/1），甘肃省教育厅，甘肃省青年教师成才奖，2020年

4.冯若飞（8/11）科研成果，甘肃省人民政府，甘肃省科技进步奖，二等奖，2020年

5.冯若飞（3/8）教学成果，国家民族事务委员会，教学成果二等奖，2019年

6.冯若飞（7/8）科研成果，中国医疗保健国际交流促进会，科技奖，二等奖，2018年

7.冯若飞（7/9），科研成果，甘肃省人民政府，甘肃省科技进步奖，二等奖，2012年

五、代表性科（教）研项目

1.国家自然科学基金项目，脑心肌炎病毒候选受体ICAM-1的受体功能和应答机制研究，202201-202612，33万，主持人

2.国家自然科学基金项目，脑心肌炎病毒受体的筛选、鉴定及功能分析，201501-201812，52万，主持人

3.甘肃省重点研发项目，基于CHO细胞高效表达平台开发融合蛋白制品及疫苗，202601-202812，50万，主持人

4.兰州市人才创新创业项目，重组人血清白蛋白在CHO细胞中高效表达技术研究，202001-202112，20万，主持人

5.甘肃省高等学校青年博士基金，宿主免疫限制因子IFITMs对脑心肌炎病毒感染的调控作用及机制，202110-202209，16万，主持人

六、代表性论著

1.Ruofei Feng（通讯作者）. PDIA3 and CANX counteract EMCV-induced cytosolic calcium elevation by targeting FGFR4 to restrict viral replication. Vet Microbiol. 2026 Oct 17;323:111260. doi: 10.1016/j.vetmic.2026.111260. Epub ahead of print. PMID: 42950766.

2.Ruofei Feng（通讯作者）. ICAM-1 functions as a functional receptor for encephalomyocarditis virus and reveals a compensatory interplay with ICAM-4. Cell Rep. 2026 Oct 27;45(10):118155. doi: 10.1016/j.celrep.2026.118155. Epub 2026 Oct 15. PMID: 42879278.

3.Ruofei Feng（通讯作者）. CHO-K1 cell-derived scFv targeting pseudorabies virus ameliorates multi-organ viremia and improves animal survival in a lethal infection model. Front Microbiol. 2026 Aug 10;17:1893255. doi: 10.3389/fmicb.2026.1893255. PMID: 42639031; PMCID: PMC13500513.

4.Ruofei Feng（通讯作者）. Encephalomyocarditis virus impairs the blood-brain barrier by degrading tight junction proteins via AKT3-dependent autophagic and apoptotic pathways. Virulence. 2026 Dec;17(1):2697518. doi: 10.1080/21505594.2026.2697518. Epub 2026 Jul 3. PMID: 42397844; PMCID: PMC13336293.

5.Ruofei Feng（通讯作者）. EMCV Non-Structural Protein 2C Antagonizes cGAS-STING-Mediated Type I Interferon Signaling via Promoting K48-Linked Polyubiquitination and Degradation of STING. Viruses. 2026 Apr 5;18(4):438. doi: 10.3390/v18040438. PMID: 42043227; PMCID: PMC13119741.

6.Ruofei Feng（通讯作者）. YWHAZ downregulated innate immune responses to RNA viruses by inhibiting the IRF3 signaling pathway. mSphere. 2026 Apr 28;11(4):e0003826. doi: 10.1128/msphere.00038-26. Epub 2026 Apr 3. PMID: 41931065; PMCID: PMC13123716.

7.Ruofei Feng（通讯作者）. Gallic acid inhibits EMCV infection via targeting the interaction between TBK1 and IRF3 to promote IFN-β expression. Microbiol Spectr. 2025 Dec 2;13(12):e0152425. doi: 10.1128/spectrum.01524-25. Epub 2025 Oct 20. PMID: 41114500; PMCID: PMC12671161.

8.Ruofei Feng（通讯作者）. 18β-glycyrrhetinic acid-amantadine hybrid: Synthesis and anti-EMCV activity via NF-κB modulation. Bioorg Med Chem. 2025 Dec 15;131:118431. doi: 10.1016/j.bmc.2025.118431. Epub 2025 Oct 3. PMID: 41066960.

9.Ruofei Feng（通讯作者）. An RNAi Therapy That Attenuates Multi-Organ Viremia and Improves Animal Survival in a Lethal EMCV Challenge Model. Viruses. 2025 Sep 14;17(9):1240. doi: 10.3390/v17091240. PMID: 41012668; PMCID: PMC12474460.

10.Ruofei Feng（通讯作者）. ICAM-1-mediated Src signaling pathway plays a pivotal role in encephalomyocarditis virus entry. J Virol. 2025 Aug 19;99(8):e0071525. doi: 10.1128/jvi.00715-25. Epub 2025 Jul 9. PMID: 40631914; PMCID: PMC12363205.

11.Ruofei Feng（通讯作者）. A candidate multi-epitopes vaccine against encephalomyocarditis virus confers protection in mice. Vet Microbiol. 2025 Aug;307:110621. doi: 10.1016/j.vetmic.2025.110621. Epub 2025 Jun 26. PMID: 40592123.

12.Ruofei Feng（通讯作者）. Linker histone H1.3 promotes IFN-β production targeting MDA5 signaling to inhibit EMCV infection. Mol Immunol. 2025 Aug;184:137-148. doi: 10.1016/j.molimm.2025.06.005. Epub 2025 Jun 27. PMID: 40580683.

13.Ruofei Feng（通讯作者）. Ionized Angelica polysaccharides derivatives slow tumor growth in vivo and induce the apoptosis of HepG2 cells via mitochondria death receptor-mediated pathways in vitro. Int J Biol Macromol. 2025 Jun;315(Pt 1):144297. doi: 10.1016/j.ijbiomac.2025.144297. Epub 2025 May 16. PMID: 40383338.

14.Ruofei Feng（通讯作者）. Encephalomyocarditis virus non-structural protein 2C induces the degradation of NDP52 autophagy protein to promote its own survival. Vet Microbiol. 2025 Jul;306:110549. doi: 10.1016/j.vetmic.2025.110549. Epub 2025 May 7. PMID: 40373618.

15.Ruofei Feng（通讯作者）. Extracellular vesicles engineered to directly target encephalomyocarditis virus ameliorates multi-organ viremia in a lethal infection model. Vet Microbiol. 2025 May;304:110448. doi: 10.1016/j.vetmic.2025.110448. Epub 2025 Mar 3. PMID: 40086011.

16.Ruofei Feng（通讯作者）. Porcine epidemic diarrhea virus nsp14 inhibited IFN-Ⅰ production by targeting RIG-I for degradation. Virology. 2025 Apr;605:110451. doi: 10.1016/j.virol.2025.110451. Epub 2025 Feb 12. PMID: 39986258.

17.Ruofei Feng（第一作者）. EMCV VP2 degrades IFI16 through Caspase-dependent apoptosis to evade IFI16-STING pathway. Virol J. 2024 Nov 18;21(1):296. doi: 10.1186/s12985-024-02568-8. PMID: 39551733; PMCID: PMC11571899.

18.Ruofei Feng（通讯作者）. The complex interplay between encephalomyocarditis virus and the host defence system. Virulence. 2024 Dec;15(1):2383559. doi: 10.1080/21505594.2024.2383559. Epub 2024 Jul 27. PMID: 39066684; PMCID: PMC11285270.

19.Ruofei Feng（通讯作者）. Pseudorabies virus VHS protein abrogates interferon responses by blocking NF-κB and IRF3 nuclear translocation. Virol Sin. 2024 Aug;39(4):587-599. doi: 10.1016/j.virs.2024.05.009. Epub 2024 May 30. PMID: 38823782; PMCID: PMC11401465.

20.Ruofei Feng（通讯作者）.Encephalomyocarditis Virus Structural Protein VP3 Interacts with MAVS and Promotes its Autophagic Degradation to Interfere with the Type I Interferon Signaling Pathway. Front Biosci (Landmark Ed). 2024 Jul 25;29(7):273. doi: 10.31083/j.fbl2907273.  

21.Ruofei Feng（通讯作者）.The complex interplay between encephalomyocarditis virus and the host defence system. Virulence. 2024 Dec;15(1):2383559. doi: 10.1080/21505594.2024.2383559.

22.Ruofei Feng（通讯作者）.Pseudorabies virus VHS protein abrogates interferon responses by blocking NF-κB and IRF3 nuclear translocation. Virol Sin. 2024 May 30:S1995-820X(24)00078-6. doi: 10.1016/j.virs.2024.05.009.

23.Ruofei Feng（通讯作者）. Mammalian orthoreovirus capsid protein σ3 antagonizes RLR-mediated antiviral responses by degrading MAVS. mSphere. 2024 Jun 25;9(6):e0023624. doi: 10.1128/msphere.00236-24. Epub 2024 May 17.  

24.Ruofei Feng（通讯作者）.Pseudorabies virus UL38 attenuates the cGAS-STING signaling pathway by recruiting Tollip to promote STING for autophagy degradation. Virol J. 2024 May 8;21(1):107. doi: 10.1186/s12985-024-02379-x.  

25.Ruofei Feng（通讯作者）.Mammalian reovirus µ1 protein attenuates RIG-I and MDA5-mediated signaling transduction by blocking IRF3 phosphorylation and nuclear translocation. Mol Immunol. 2024 Jun;170:131-143. doi: 10.1016/j.molimm.2024.04.010.

26.Ruofei Feng（通讯作者）.New perspective of small-molecule antiviral drugs development for RNA viruses. Virology. 2024 Jun;594:110042. doi: 10.1016/j.virol.2024.110042.

27.Ruofei Feng（通讯作者）.Histone H1.2 Inhibited EMCV Replication through Enhancing MDA5-Mediated IFN-β Signaling Pathway. Viruses. 2024 Jan 24;16(2):174. doi: 10.3390/v16020174.

28.Ruofei Feng（通讯作者）. Construction, expression and assemble of EMCV VLPs and their potency evaluation. Virology. 2023 Jul;584:1-8. doi: 10.1016/j.virol.2023.04.011.  

29.Ruofei Feng（通讯作者）. IFITM2 Presents Antiviral Response through Enhancing Type I IFN Signaling Pathway. Viruses. 2023 Mar 28;15(4):866. doi: 10.3390/v15040866.  

30.Ruofei Feng（通讯作者）. HSP27 Attenuates cGAS-Mediated IFN-β Signaling through Ubiquitination of cGAS and Promotes PRV Infection. Viruses. 2022 Aug 23;14(9):1851. doi: 10.3390/v14091851.

31.Ruofei Feng（通讯作者）. DDX56 inhibits PRV replication through regulation of IFN-β signaling pathway by targeting cGAS. Front Microbiol. 2022 Aug 10;13:932842. doi: 10.3389/fmicb.2022.932842.  

32.Ruofei Feng（通讯作者）. Pseudorabies Virus ICP0 Abolishes Tumor NecrosisFactor Alpha-Induced NF-κB Activation by Degrading P65. Viruses. 2022;14(5):954. Doi:10.3390/v14050954.  

33.Ruofei Feng（通讯作者）. DDX56 antagonizes IFN-β production to enhance EMCVreplication by inhibiting IRF3 nuclear translocation[J].Vet Microbiol. 2021 Dec13;264:109304. Doi: 10.1016/j.vetmic.2021.109304.  

34.Ruofei Feng（通讯作者）.  HSP27 ProteinDampens Encephalomyocarditis Virus Replication by Stabilizing MelanomaDifferentiation-Associated Gene 5. Front Microbiol. 2021 Nov 26;12:788870. Doi:10.3389/fmicb.2021.788870.

35.Ruofei Feng（通讯作者）. Pseudorabies Virus US3 Protein Inhibits IFN-β Productionby Interacting With IRF3 to Block Its Activation[J].Front Microbiol. 2021 Oct22;12:761282. Doi: 10.3389/fmicb.2021.761282.  

36.Ruofei Feng（通讯作者）. Host protein, HSP90β, antagonizes IFN-β signalingpathway and facilitates the proliferation of encephalomyocarditis virus invitro[J].Virus Res. 2021 Nov;305:198547. Doi: 10.1016/j.virusres.2021.198547.  

37.Ruofei Feng（通讯作者）.Encephalomyocarditis virus abrogates the IFN-βsignaling pathway via its structural protein VP2[J].Journal of Virology,2020.12. Doi: 10.1128/JVI.01590-20.  

38.Ruofei Feng（通讯作者）. TransmembraneProtein 39A Promotes the Replication of Encephalomyocarditis Virus via AutophagyPathway[J]. Front. Microbiol., 2019;10:2680. Doi: 10.3389/fmicb.2019.02680.

39.Ruofei Feng（通讯作者）. Host antiviral protein IFITM2 restrictspseudorabies virus replication[J]. Virus Res., 2020; 287: 198105. Doi:10.1016/j.virusres.2020.198105.

40.RuofeiFeng(通讯作者). Construction, expression,and characterization of a single-chain variable fragment (ScFv) antibodytargeting to the encephalomyocarditis virus. J Med Virol. 2018 Feb 24. Doi: 10.1002/jmv.25065.  

41.RuofeiFeng(通讯作者).Transcriptional profiling ofhost cell responses to encephalomyocarditis virus (EMCV). Virol J. 2017 Mar 4;14(1):45. Doi: 10.1186/s12985-017-0718-4.  

42.RuofeiFeng(第一作者). National serosurvey of encephalomyocarditisvirus in healthy people and pigs in China. Archives of Virology. 2015 Dec;160(12):2957-64.Doi: 10.1007/s00705-015-2591-z)

43.RuofeiFeng(第一作者).Isolation, molecular andphylogenetic analysis of encephalomyocarditis virus strain GS01 in China. Infect Genet Evol. 30(2015):19-26.Doi:10.1016/j.meegid.2014.12.004  

44.RuofeiFeng(第一作者).Infection dynamics ofhepatitis E virus in naturally infected pigs in a Chinese farrow-to-finishfarm. Infect Genet Evol. 2011,11:1727-1731. Doi:10.1016/j.meegid.2011.07.009