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周建业
作者:周建业    编辑:吴赛     校审:           发布时间:2024-01-23    访问量:

周建业,汉族,19786月出生。博士,教授,硕士生导师。国家民委青年英才,中国非公立医疗机构协会口腔预防专委会主委,中国非公立医疗机构协会研发中心常务副主任,甘肃生物工程学会科普与教育专委会主委主持并以主要完成人参与国家自然科学基金5项,主持并以主要完成人参与省部级项目20多项,主持横向基金3项;发表论文80余篇获得省级科技创新创业二等奖1项,获地级进步一等奖1为团队成员,获得国家科技创新团队奖1项;获得发明专利6项,实用新型专利3近年来,注重基础研究与产业转化的结合。在口腔核磁,等离子刀,口腔护理产品等方面带队做出重要成果,并使相关企业达到3亿以上产值。

课题:

1甘肃特有少数民族儿童口腔微生物群体感应与龋病的相互关系研究,20181-202112月,2017国家自然科学基金地区基金项目(31560159)3/1045万。

2甘肃省科技厅:一种新型颌骨骨支架材料的开发,20YF3GA02020211-202212月,25万。

3基于3D打印的数字化口腔医疗器械研发及应用研究,梅108号;20208-20228月,300万(横向项目)。

4冰核细菌在中草药绿色种植病虫害防治中的应用,FXH202000220206-20216月;30万(横向项目)。

5筛选及培养高通量药物筛选平台的建立,LTY202000820206-20216月;100万(横向项目)。

6保安族牙周炎中免疫与微生物群落结构研究,20171-201912月,2017西北民族大学中央高校重点培育项目(31920170162),1/913万。

7甘肃临夏回族自治州学龄儿童龋病微生物群落结构及其影响机理研究,20151-201912月,2015国家自然科学基金地区基金项目(31560159),1/1045万。

8Apidaecin抗菌肽在毕赤酵母高效分泌表达的反应器开发与研究,20115-201312月,2011年甘肃省科技支撑计划项目,1/65万。

9口腔微生物与口腔常见疾病的关系研究,20181-202112月,2017甘肃省创新群体研究项目(17JR5RA274),3/1050万。

10舌鳞状细胞癌患者口腔微生物群落结构多样性的研究,20169-20188月,2016甘肃省省青年科技基金计划项目(1606RJYA238),2/102万。

11 甘肃特有少数民族龋病相关微生物的生态遗传特征研,20141-201712月,2014国家自然科学基金地区基金项目(31360124),3/1051万。

12龋病、牙周炎微生物拮抗机理及预防试剂研发(20141-201612月),2013年甘肃省科技厅国际合作项目,2/1020万。

13甘肃省特有少数民族口腔微生物群落结构与牙周炎发病的关系研究,20141-201712月,2012国家自然科学基金地区基金项目(31160124),3/1056万。

14甘肃省特有少数民族龋病分子流行病学研究(20111-201312)2010甘肃省科技厅国际合作项目(1011WCGA168),2/1010万。

15EGFP转染牙龈卟啉单胞菌及其在种植体周围炎中的定植研究,20131-201512月,2012年度甘肃省自然科学基金计划项目(1208RJZA201),2/103万元。

16、甘肃特有少数民族儿童口腔微生物群体感应与龋病的相互关系研究项目,批准号:31760159/ C0309国家自然科学基金委,45万,2/10, 年限:2018.01-2021.12

172019扶贫助弱 健康口腔——甘肃临夏州少数民族全生命周期口腔健康扶贫示范项目,经费49.9万元,中国牙病防治基金会

18、口腔微生物与口腔常见疾病的关系研究   项目批准号:17JR5RA274,甘肃省科技厅基础研究创新群体,50万,年限:2017.01-2021092/12

1920202022年校级生物材料创新团队,60

2020239月甘肃省科技计划项目高原地区急性心肌梗死患者口腔菌群和肠道菌群特征分析”3


主要论文:

(1) Guoyun Ma, Liya,Ma, Zhou J*, et al. Comparison of oral microbial community structure among the same ethnic group in different living environments[J]. BioMed Research International.2022:4(5)

(2) Ikram Khan, Imran Khan3,... Zhou J, et al. Comparison of Microbial Populations in the Blood of Patients With Myocardial Infarction and Healthy Individuals.Frontiers in Microbiology,2022:

(3) Ikram Khan, Imran Khan3,... Zhou J, et al. Analysis of the blood bacterial composition of patients with acute  coronary syndrome and chronic coronary syndrome. Frontiers in cellutar and infection microbiology.

(4) Khan I, Khan I, Jianye Z, et al. Exploring blood microbial communities and their influence on human cardiovascular disease[J]. Journal of Clinical Labora- tory Analysis, 2022: e24354.(1)

(5) Khan I, Khan I, Jianye Z, et al.Analysis of mitochndrial DNA mutation in pakistani women gestations diabetes melltitus. Intenational journal of biomedicine

(6) Wu S, Yu F, Zhou J*, et al. Do Maternal Microbes Shape Newborn Oral Microbes?[J]. Indian Journal of Microbiology, 2020.

(7)Xiao Ma, Xuefei Zhang, Jia Liu.,Zhou J. The correlations between Th1 and Th2 cytokines in human alveolar echinococcosis, BMC Infectious Diseases 2020,doi: 10.21203/rs.2.21197/v1 (2)

(8) Li Y , Gao X , Zhou J. et al. Modification of Mcl-1 alternative splicing induces apoptosis and suppresses tumor proliferation in gastric cancer[J]. (2020) Aging, 12(19):19293-19315.a

(9) Zhou J, Jiang N, Wang Z, Li L, Jumei Zhang, Ma R, Nie H , Li Z. Influences of pH and iron on the salivary microbiome in individuals with and without caries.[J]. Applied and environmental microbiology, 2017, 83(4): e02412-16.

(10) Zhou J, Yao Y, Jiao K, Zhang J, Zheng X, Wu F, Hu X, Li J, Yu Z, Zhang G, Jiang N, Li Z. Relationship between Gingival Crevicular Fluid Microbiota and Cytokine Profile in Periodontal Host Homeostasis[J]. Frontiers in Microbiology, 2017, 8:2144.

(11) Yao Y, Wei Y, Wei L, Zhou J*. Effect of Inoculum on Anaerobic Co-digestion of Vegetable Processing Wastes and Cattle Manure at High Solids Concentration[J]. Waste& Biomass Valorization, 2017(6):1-8. (9)

(12) Zhou J, Jiang N, Wang S, Hu X, Jiao K, He X, Li Z, Wang J.. Exploration of Human Salivary Microbiomes—Insights into the Novel Characteristics of Microbial Community Structure in Caries and Caries-Free Subjects[J]. PloS one, 2016, 11(1): e0147039.

(13) Zhou J, Zhu Y, Yu Z, Jiao K, Wu F, Li Z. Microbial community structure in saliva from children of the Baoan nationality with or without dental caries in gansu, China[J]. Biomedical Research, 2017, 28(1): 306-308.

(14) Yao Y, Zhou J*,An L, Kafle G K, et al. Role of soil in improving process performance and methane yield of anaerobic digestion with corn straw as substrate[J]. Energy, 2018, 151

(15) Zhou J, Jiang N, Jiao K, Yu Z, Zheng X, Zhang J, Wu F, Li J, Li Z. Bacterial community of saliva in adults with and without periodontitis[J]. International journal of clinical and experimental medicine2016, 9(8): 16192-16198.

(16) Huang H,Chen L, Zhang X, Wu S, Yi G, Li Z, Zhou J#. "Untargeted metabolomics analysis for a strain of Bacillus subtilis isolated from the oral cavity." INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE 11.4 (2018): 3729-+.

(17) Hu X, Li Z, Zhou J, Yu Z, Zhang J, Guo M. Analysis of the association between polymorphisms in the vitamin D receptor (VDR) gene and dental caries in a Chinese population[J]. Genet Mol Res, 2015, 14(3): 11631-11638.

(18) Li Z, Hu X, Zhou J, Li Z, Hu X, Zhou J, Xie X, Zhang J. Genetic polymorphisms in the carbonic anhydrase VI gene and dental caries susceptibility[J]. Genet Mol Res, 2015, 14(4): 5986-5993.

(19) Tingli Zhang,Yonghong Li, Zhou J. et al. "Comparison of the community-acquired

pneumonia and COVID-19 at the early stage: Findings from two cohort studies”Annals of Palliative Medicine, (2021)21-2006,

(20) Xiao-Pan Hu1, Tian-Zhu Song1, Yan-YanZhu1,Zhou J. et al.Associationof ENAM, TUFT1,MMP13, IL1B, IL10 and IL1RNgene polymorphism anddental cariessusceptibilityin Chinese children   Journal of InternationalMedical Research  2019, Vol. 47(4) 1696–1704

(21)Lingli Wu, Zhiqiang Li, Zhou J. et An association analysis for genetic factors for dental caries susceptibility in a cohort of Chinese children[J]. Oral Diseases, 2020.

(22) Khan I, Khan I, . Zhou J. et Circulating microbiota and metabolites: Insights into cardiovascular diseases J Clin Lab Anal. 2022;00:e24779.

(23) Tingli Zhang,Yonghong Li, Zhou J. et al. "Comparison of the community-acquired

pneumonia and COVID-19 at the early stage: Findings from two cohort studies”Annals of Palliative Medicine, (2021)21-2006

(23)Fangchen, Liu;Rui, Ma; Zhou J. et al. The Influence of Different Pore Sizes of Bovine Bone Scaffold Material on the Oral Microbiota. Journal of Biomaterials and Tissue Engineering. 2023.05

(24)Cheng, XRui, Ma; Zhou J. et al.Preparation and osteogenic properties of β-TCP+HA+GO Composites. Journal of Biomaterials and Tissue Engineering. 2023.06

(25)Ikram Khan, Gao Jianli, Mian Gul Hilal, Lei Shengnan, Imran Khan, Naqash Alam, Zhou Jianye, Li Zhiqiang, and An Lizhe. (2022). Glucose: an ongoing risk factor for myocardial infarction. Cardiology research and cardiovascular medicine. www.doi.org.10.29011/2575-7083-100183.

(26) Ikram Khan, Anum A, Khan I, Khan M, Ali F, Khan S, Khan F, Zhou Jianye, Lizhe A, Zhiqiang L. (2022). Analysis of Mitochondrial DNA Mutation in Pakistani Women with Gestational Diabetes Mellitus. International Journal of Biomedicine. doi.org/10.21103/Article12(3)_OA17.

(27) Xiao-Pan Hu1, Tian-Zhu Song1, Yan-YanZhu1,Zhou J. et al.Associationof ENAM, TUFT1,MMP13, IL1B, IL10 and IL1RNgene polymorphism anddental cariessusceptibilityin Chinese children   Journal of InternationalMedical Research  2019, Vol. 47(4) 1696–1704

(28)Lingli Wu, Zhiqiang Li, Zhou J. et An association analysis for genetic factors for dental caries susceptibility in a cohort of Chinese children[J]. Oral Diseases, 2020.


授权专利

1. 具有减振防旋功能的牙科种植体, 2015.10.28,中国,201220375036.4周建业,陈宏伟,王记增,周又和,李志杰,范勤,刘斌。

2. 一种酸激活CSP靶向抗菌肽及其制备和应用,2015.07.29, 中国,01210314814.3周建业,张伟,王记增,林志伟,陈熙明,李志杰。

3. 偏心轴式半固定阻鼾器,2015.10.28,中国,ZL201310169423.1周建业, 李志强,胡晓潘,张轩,焦康礼,王记增。

4. 一种骨支架复合材料的制备方法;发明专利;专利号:ZL201710512368.X

5. 实用新型专利:专利名称:一种采样拭子取样头及新型人体采样硅胶拭子;专利号:202020413456.X

6. 2022/02/18 白仲添,张保新,席莉莉,周建业, 国家发明专利, PCID2蛋白在制备或筛选抗肿瘤药物中的应用及具有抗肿瘤活性的化合物(ZL2021 1 0364129.0). 申请日期: 2021/4/3

7. Zhou, Jianye; Jiao, Kangli; Zhang, Xuan; Song, Tianzhu; Zhang, Jumei; Zheng, Xin; Hu, Xiaopan; Li, Zhiqiang and Xie, Xiaodong A Preparation Method of Bone Scaffold Composite Material Patent number: 2021103980


获得学术奖励


1. 周建业,(2/13),甘肃省特有少数民族龋病的分子流行病学研究,甘肃省教育厅,甘肃省高等学校科学研究优秀成果奖自然科学奖,一等奖(批准号:2015KJ-207),2015.

2. 地级科技进步奖1项:周建业,(1/2),青海省海西州科技创新奖;三等奖;获奖名称:一种新型颌骨骨支架材料的研究与制备,2021.

3. 马忠仁、柏家林、冯若飞、周建业等,国家科技创新团队奖,2021.


4. 周建业等,甘肃省科技厅创新创业奖,二等奖,青少年心理健康预警机器人研发. 2022


著作

1、周建业 林永盛 实用口腔健康管理,中国科学技术出版社,2023.9

2、周建业  颌骨修复中复合材料的应用,中国科学技术出版社,2023.9



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