生物技术系

一、 基本信息

姓名：张浩

学历：研究生

学位：博士

毕业院校：北京师范大学

职称：副教授

二、 研究专长

主要研究领域：生物信息学、计算生物学、计算化学

研究方向：酶催化反应机理的进化，旨在构建磷酸酶催化结构与机理的进化关系；生命信息系统建模与特征提取方法，探索人工智能和数据挖掘方法在生命科学中的应用；围绕生物学问题的复杂系统建模，探索未来的人工智能模型框架。

三、教学情况

本科生教学 讲授《生物化学》

四、 主要科研成果

代表性论文(一作以及通讯作者)：

1.Zhang, H., Ma, Y., Liu, K. & Yu, J.-G. (2013) Theoretical studies on the reaction mechanism of PP1 and the effects of different oxidation states of the Mn–Mn center on the mechanism. Journal of Biological Inorganic Chemistry 18, 451-459.

2.Zhang, H., Ma, Y. & Yu, J.-G. (2013) Theoretical studies on the mechanism of activation of phosphoprotein phosphatases and purple acid phosphatases suggest an evolutionary strategy to survive in acidic environments. Journal of Biological Inorganic Chemistry 18, 1019-1026.

3.Zhang, H., Yang, L., Ding, W., and Ma, Y. (2018) The pH-dependent activation mechanism of Ser102 in Escherichia coli alkaline phosphatase: a theoretical study. Journal of Biological Inorganic Chemistry 23, 277-284.

4.Zhang, H., Yang, L., Yan, L.-F., Liao, R.-Z. (2018) Evolution of phosphotriesterase activities of the metallo-β-lactamase family: A theoretical study. Journal of inorganic biochemistry 184, 8-14.

5.Zhang, H., Yang, L.,. & Ma, Y. (2018) Theoretical Studies on the Catalytic Cycle of Histidine Acid Phosphatases Revealing an Acid Proof Mechanism. Journal of Physical Chemistry B 122, 7530.)

6.Zhang, H., Yang, L., Ma, Y.-Y., Zhu, C., Lin, S. & Liao, R.-Z. (2018) Theoretical Studies on Catalysis Mechanisms of Serum Paraoxonase 1 and Phosphotriesterase Diisopropyl Fluorophosphatase Suggest the Alteration of Substrate Preference from Paraoxonase to DFP. Molecules 23, 1660.

7.Wang, L., Yang, L., Feng, Y.-l., Zhang, H.* (2020) Evolutionary insights into the active-site structures of the metallo-β-lactamase superfamily from a classification study with support vector machine. Journal of Biological Inorganic Chemistry, 25 (7), 1023-1034.

8.Yang, L., Lu, Y., Tian, W., Feng, Y.-l., Bai, J., Zhang, H.* (2021) Insights into the functional divergence of the haloacid dehalogenase superfamily from phosphomonoesterase to inorganic pyrophosphatase. Archives of Biochemistry and Biophysics 705, 108896.

9. Zhang, M., Yang, L., Ding, W., and Zhang, H.* (2022) The His23 and Lys79 pair determines the high catalytic efficiency of the inorganic pyrophosphatase of the haloacid dehalogenase superfamily. Biochimica et Biophysica Acta (BBA) - General Subjects 1866, 130128.

10. Zhang, H., Zhang, M., Zhu, K., Feng, Y._, Yang, L., Ding, W. (2025) Unraveling the Mechanism: How does β-Phosphoglucomutase from the Haloacid Dehalogenase Superfamily Catalyze the Interconversion of β-D-Glucose 1-Phosphate and β-D-Glucose 6-Phosphate? A Chemical Perspective. Journal of inorganic biochemistry 264, 112794.

11.Zhang, H., Qi, Y., Wang, L. (2026) UniWave: A Waveform-Based Encoding Framework for Nucleic Acid Feature Extraction. bioRxiv 2026.01.12.698567, doi: https://doi.org/10.64898/2026.01.12.698567. (Preprint)

个人专著：

著有《经史杂谈》（陕西师范大学出版总社 2024年出版）一书，经略贯穿三皇五帝至隋末唐初历史，经书史书杂而治之。全书用理学视角审视历史——在较长的时间尺度、较宽的空间范围内，探索个体、家族、团体乃至邦国，是如何在复杂社会系统中演化。